Figure 4.

Linkage disequilibrium across the NBN gene and neighbouring chromosomal region. Upper part shows linkage disequilibrium (LD) results (r² and |D'|) obtained from the control genotypes data used in our study and their relative position along NBN sequence. In the bottom part of the figure are indicated r² data from the International HapMap project (release 21a) for the genomic region encompassing NBN. The intensity of the box color is proportional to the strength of LD. r² = 0 in white; 0 < r² < 1 in shades of pink/red; r² = 1 in bright red.