Figure 4.

Slow adaptation in Myo15 ^sh2/sh2 IHCs. A, B, SEM examination (A) and MET responses (B) in an experiment with one of the most prominent adaptation in Myo15 ^sh2/sh2 IHCs. Inset in A shows top-to-top stereocilia links; the specimen is viewed from an ∼30° angle. Age of the specimen was P3 + 2 d in vitro. Scale bars: A, 1 μm; A, inset, 100 nm. C, Scatter plot of the time constants of adaptation in Myo15 ^sh2/sh2 IHCs and slow adaptation in Myo15 ^+/sh2 IHCs versus maximum MET current. The same set of experiments as in Figure 3. Time constants of slow adaptation in Myo15 ^+/sh2 IHCs were determined for MET responses to 300–600 nm deflections by fitting these responses to double exponential function.