Table 4.

Gene clusters identified using Ingenuity Path Analysis in preelcamptic placenta.

Genes in Network	Score	Focus genes	Functions
AKT2, ASS1, AZGP1, beta-estradiol, CASP14, CDO1, CTSH, CYP24A1, FSTL3, GAL, GCLC, HEXB, HRASLS3, IFIT3, IFNG, IGFBP4, IGSF1, INHA, MBP, MOG, MXI1, MYOD1, NPY1R, NXPH1, PCSK1, PMM2, prostaglandin E2, PYGM, SLCO2A1, TCF12, TEAD2, TGFB1, TNFRSF11B, VGLL1, ZFP36	30	14	Cellular Development, Hematological System Development and Function, Immune and Lymphatic System Development and Function
ADRB3, Akt, ASS1, BCL6, BSG, CDKN1C, CPT1A, CSF2RA, DLL4, EBI3, F2R, FCGR1A, FCGR2B, FLT1, GCLC, HMOX1, IL9, IL5RA, IL9R, LEP, Mapk, NR4A2, P38 MAPK, PDE3B, PMCH, PRKAA1, RETN, RUNX1T1, SHC2 (includes EG:25759), SLC25A5, STAT5a/b, UCN, Vegf, Vegf Receptor, VEGFB (includes EG:7423)	28	13	Cell Death, Cellular Growth and Proliferation, Inflammatory Disease
4-androstene-3,17-dione, ABCB11, ABCC3, ASS1, carbon monoxide, CYP11A1, CYP2E1, CYP7A1, FCGR2B, GCLC, GHRL, GRN, Gsk3, HMGCR, HSD11B1, IGFBP4, IL27, IL10RA, IL1B, LAD1, Nos, NR4A2, NR4A3, ORM2, PGF, PROCR, PRTN3, RPSA, SCARB1, SEPP1, TFAP2C, TG, THBD, TNF, TNFRSF11B	8	5	Cellular Growth and Proliferation, Small Molecule Biochemistry, Connective Tissue Development and Function

^*The networks were generated through the use of Ingenuity Pathways Analysis (Ingenuity® Systems, www.ingenuity.com). Each gene identifier was mapped to its corresponding gene object in the Ingenuity Pathways Knowledge Base (IPKB). These genes were overlaid onto a global molecular network developed from information contained in the IPKB. Network enrichment is then assessed using a network score (negative log of p-values of Fisher tests). Focus genes (in bold) are genes identified in our list of differentially expressed genes. Networks shown here are those with network scores > 3.0.