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Metabolism of methylglyoxal. In T. cruzi and L. major, the principal end-product of methylglyoxal metabolism is d-lactate. In the absence of GLO1, T. brucei does not maintain an intact glyoxalase system, and may metabolize methylglyoxal via methylglyoxal reductase (MeGR) and lactaldehyde dehydrogenase (LADH) to l-lactate. Solid lines: confirmed metabolism in T. brucei. Dotted lines: metabolism absent in T. brucei. MeGDH, methylglyoxal dehydrogenase; LDH, lactate dehydrogenase.
