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. 2009 Jun;50(3):207–217. doi: 10.3325/cmj.2009.50.207

Figure 1.

Figure 1

(A) With sufficient DNA, eg, 250 pg, faithful reproduction of the alleles can be generated. (B) Possible stochastic effects when a low copy number (LCN) sample containing approximately 36 pg of DNA is analyzed. The result can be heterozygote peak imbalance, allele drop-out (or a pseudo-homozygote profile), increased stutter, or combinations thereof. (C) The possible stochastic effects when a LCN sample containing approximately 36 pg of DNA is analyzed. Due to increased sensitivity of detection the risk of allele-drop in (and allele drop-out) is exacerbated.