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. Author manuscript; available in PMC: 2009 Jun 29.
Published in final edited form as: Nat Clin Pract Nephrol. 2007 Mar;3(3):164–170. doi: 10.1038/ncpneph0418

Figure 4.

Figure 4

Model of molecular interactions involved in RANTES transcription. See text for details. (A) Signal transduction and the RANTES enhancesome. (B) Chromatin state in resting and activated T lymphocytes. Abbreviations: AC, acetylation; AP-1, activator protein 1; Brg-1, Brahma-related gene 1 protein (ATPase); cAMP, cyclic AMP; CBP/p300, cyclic AMP response element binding protein/p300; CRE, cyclic AMP response element; CREB/ATF, phospho-cAMP response element binding protein/activation transcription factor; G, G protein; H, histone; Jun D, transcription factor jun-D; K+, potassium; K8, lysine at amino acid 8; K14, lysine at amino acid 14; KLF13, Krueppel-like factor 13; Me, methylation; NLK, Nemo-like kinase; P, phosphorylation; PCAF, p300/CBP-associated factor; PIP2, phosphoinositol phosphate 2; PKC, protein kinase C; Pol II, polymerase II; PRMT1, protein arginine N-methyltransferase 1; RANTES, regulated upon activation, normal T cell expressed and secreted; R3, arginine at amino acid 3; S10, serine at amino acid 10.