Table 5.

Results of mixed effects regression modeling to examine changes in problems over time ^* by type of side effect and population used in the analysis

Type of problem	Analysis groups
	All	Completers	Incompleters	LOCF
Last menses
Level of menstrual pain compared to before the IUD
Follow-up form	Decreasing	Decreasing	No change	Decreasing
Menstrual diary**	Decreasing	--	--	--
Amount of blood loss compared to before the IUD
Follow-up form	Decreasing	Decreasing	No change	Decreasing
Menstrual diary**	Decreasing	--	--	--
Days of bleeding	No change	No change	Increasing	No change
Last intermenstrual interval
Any pain	No change	No change	No change	No change
Number of pain days	Increasing	No change	Increasing	Increasing
Any spotting	No change	No change	No change	No change
Number of spotting days	Increasing	No change	Increasing	No change
Serious problems
Any pain	Decreasing	Decreasing	No change	No change
Menstrual bleeding	No change	No change	Increasing	Increasing
Intermenstrual spotting	Increasing	No change	Increasing	Increasing

^*Labeled as decreasing or increasing trend if p value < 0.05. Otherwise, labeled as “no change.”

^**Available for first six months only. Subgroup analyses not performed due to concerns over validity.

All=all available data. Completers=only women who used the IUD for one full year. Incompleters=only women who had the IUD removed before one year.

LOCF (last observation carried forward) = all available data and imputation for data points after an IUD removal event; the data points were imputed using the technique of last observation carried forward for only subsequent scheduled visits.