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. Author manuscript; available in PMC: 2010 Jun 25.
Published in final edited form as: Neuron. 2009 Jun 25;62(6):826–838. doi: 10.1016/j.neuron.2009.05.011

Figure 4. NMDAR LTP Requires NMDAR Activation during Synaptic Stimulation-Burst Pairing.

Figure 4

(A) Transiently blocking NMDARs with DL-AP5 (100 μM) during delivery of the induction protocol, as indicated by the black bar, prevented the development of LTP in this example experiment. Average NMDAR EPSCs taken at the times indicated are shown in inset for control (1), in AP5 (2), and after LTP induction and AP5 washout (3).

(B) Summary time graph of experiments where LTP was blocked by DL-AP5 (50–100 μM) perfused during the induction (n = 4). Summary of control experiments is also shown, where DL-AP5 (100 μM) was perfused and washed out without delivery of the induction protocol (n = 3). Error bars indicate SEM.