Skip to main content
. Author manuscript; available in PMC: 2010 Jun 25.
Published in final edited form as: Neuron. 2009 Jun 25;62(6):826–838. doi: 10.1016/j.neuron.2009.05.011

Figure 8. NMDAR LTP Can Be Reversed.

Figure 8

(A) Representative experiment showing that repeated synaptic stimulation can depotentiate previously potentiated NMDAR EPSCs. The arrow indicates LTP induction by synaptic stimulation-burst pairing, while the arrowhead indicates the delivery of the depotentiation protocol consisting of synaptic stimulation alone. Average NMDAR EPSCs taken at the times indicated are shown in inset for control (1), after LTP (2), and after depotentiation (3).

(B) Summary time graph of depotentiation experiments (n = 4). Burst pairing protocol was delivered at the arrow to induce LTP, while the depotentiation protocol was applied at the arrowhead.

(C) Time course of a representative experiment in which pairing synaptic stimulation with single postsynaptic APs during the depotentiation protocol prevented reversal of previously induced NMDAR LTP. LTP was induced at the arrow, while the synaptic stimulation-single AP pairing protocol was applied at the gray arrowhead. Average NMDAR EPSCs are shown in inset for control (1), after LTP (2), and after single-AP pairing (3).

(D) Summary time graph of experiments attempting depotentiation with single-AP pairing (n = 4).

Error bars indicate SEM.