Table 2. Spearman correlation coefficient between the PLM and ALM frequency profiles.
structural classa | TreeFam id | UniProt id | ELM id | Start | locCons corr | globCons corr |
TF106427 | P29374 | LIG_RB | 957 | −0.14 | 0.12 | |
TF106496 | P25054 | TRG_NES_CRM1_1 | 163 | −0.09 | −0.05 | |
TF316358 | P10636 | LIG_SH3_1 | 565 | −0.05 | 0.42 | |
TF300785 | P51531 | LIG_RB | 1294 | −0.01 | 0.12 | |
TF314303 | O15147 | LIG_SH3_5 | 389 | −0.01 | 0.16 | |
TF325994 | P35568 | LIG_14-3-3_3 | 267 | 0.12 | 0.29 | |
TF331759 | O60315 | LIG_CtBP | 785 | 0.16 | 0.20 | |
TF323952 | P17535 | LIG_COP1 | 241 | 0.16 | 0.33 | |
DIS DIS | TF325994 | P35568 | LIG_14-3-3_3 | 371 | 0.29 | 0.42 |
TF318445 | O35973 | TRG_NES_CRM1_1 | 488 | 0.32 | 0.50 | |
TF325994 | P35570 | LIG_SH2_GRB2 | 896 | 0.45 | 0.52 | |
TF101166 | P05205 | LIG_RB | 61 | 0.53 | 0.10 | |
TF320471 | P35712 | LIG_CtBP | 424 | 0.36 | 0.15 | |
TF313876 | Q91VZ6 | LIG_Clathr_ClatBox_l | 192 | 0.31 | 0.16 | |
TF325994 | P35570 | LIG_SH2_PTP2 | 1179 | 0.23 | 0.21 | |
TF331759 | O60315 | LIG_CtBP | 859 | 0.34 | 0.31 | |
TF323952 | P05412 | MOD_PIKK_l | 246 | 0.55 | 0.52 | |
TF105306 | Q00987 | MOD_PIKK_l | 392 | −0.02 | 0.02 | |
DIS GLOB | TF323952 | P05412 | LIG_MAPK_1 | 32 | 0.55 | 0.27 |
TF314861 | Q05140 | LIG_PIP2_ANTH_1 | 28 | 0.51 | 0.36 | |
TF325994 | P35570 | MOD_CK2_1 | 96 | 0.48 | 0.39 | |
TF335892 | P04235 | TRG_LysEnd_APsAcLL_l | 138 | 0.18 | 0.28 | |
TF300460 | Q04656 | TRG_LysEnd_APsAcLL_l | 1483 | 0.38 | 0.00 | |
TF105137 | Q02750 | LIG_MAPK_1 | 3 | 0.34 | 0.11 | |
TF300618 | P27797 | TRG_ER_KDEL_l | 414 | 0.53 | 0.22 | |
GLOB DIS | TF105135 | P45985 | LIG_MAPK_1 | 40 | 0.36 | 0.28 |
TF105115 | Q99683 | LIG_14-3-3_1 | 963 | 0.33 | 0.31 | |
TF300540 | P04040 | TRG_PTS1 | 523 | 0.38 | 0.36 | |
TF105044 | P36604 | TRG_ER_KDEL_1 | 660 | 0.45 | 0.42 | |
TF106381 | P09103 | TRG_ER_KDEL_l | 506 | 0.52 | 0.48 | |
TF105042 | P17156 | LIG_TPR | 630 | 0.65 | 0.52 | |
TF335892 | P19377 | MOD_TYR_ITAM | 146 | −0.05 | −0.08 | |
TF101211 | Q8AY27 | MOD_PIKK_l | 2 | 0.03 | 0.00 | |
TF101004 | P24385 | LIG_RB | 5 | 0.22 | 0.10 | |
GLOB GLOB | TF105115 | Q99683 | LIG_RB | 916 | 0.19 | 0.17 |
TF105122 | P28562 | LIG_MAPK_2 | 339 | 0.44 | 0.25 | |
TF315491 | P27918 | MOD_CMANNOS | 318 | 0.37 | 0.27 | |
TF105331 | Q96GD4 | LIG_APCC_Dbox_l | 314 | 0.65 | 0.53 | |
TF316520 | O00268 | LIG_HP1_1 | 762 | −0.07 | 0.01 | |
TF101065 | Q12834 | LIG_APCC_KENbox_2 | 96 | −0.01 | 0.04 | |
TF313542 | P49418 | LIG_AP2alpha_l | 324 | 0.03 | 0.15 | |
TF300772 | P49736 | MOD_PIKK_1 | 105 | 0.09 | 0.16 | |
MIXED DIS | TF105351 | P35465 | LIG_SH3_2 | 13 | 0.11 | −0.06 |
TF332149 | O75074 | TRG_LysEnd_GGAAcLL_l | 764 | 0.35 | 0.01 | |
TF106101 | P04637 | TRG_NES_CRM1_1 | 339 | 0.04 | 0.01 | |
TF318574 | Q9UJY5 | TRG_LysEnd_GGAAcLL_2 | 355 | 0.34 | 0.03 | |
TF101089 | P53350 | LIG_APCC_Dbox_l | 336 | 0.33 | 0.14 | |
TF105722 | P35251 | LIG_RB | 662 | −0.11 | −0.06 | |
TF300901 | P23396 | LIG_MAPK_2 | 77 | 0.24 | 0.41 | |
MIXED GLOB | TF333209 | P54274 | MOD_PIKK_1 | 216 | −0.08 | −0.10 |
TF318283 | P46061 | MOD_SUMO | 525 | 0.10 | −0.07 | |
TF101066 | Q8UWJ8 | LIG_CYCLIN_l | 445 | 0.31 | 0.19 | |
TF330851 | P10912 | LIG_SH2_STATB | 566 | 0.30 | 0.21 |
Spearman correlation coefficient calculated between the PLM and ALM frequency profiles of each instance. Correlation of the frequency profiles of IU Pdiff versus locCons and IU Pdiff versus globCons are indicated as locCons corr and globCons corr respectively. Correlation of 1 would indicate that the PLM and ALM sets cover the same IU Pdiff and locCons/globCons ranges. A correlation of −1 would imply that those ranges are completely disjoint and diametrically opposed (e.g. high IU Pdiff and low locCons for ALM while low IU Pdiff and high locCons for PLM). Small positive or negative values indicate that the ranges tend to be disjoint but not opposite. Instances in bold have PLM and ALM sets with significantly different IU Pdiff distributions (p-values<0.05).
protein and module structural classes.