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. Author manuscript; available in PMC: 2009 Jun 29.
Published in final edited form as: Neurosci Lett. 2008 Jun 6;440(3):260–264. doi: 10.1016/j.neulet.2008.05.112

Fig. 3. Statins inhibited hippocampal apoptotic cell death induced by KA.

Fig. 3

The rats were orally pre-treated (7 days before) with atorvastatin (LP; 10 mg/kg) prior to KA (10 mg/kg, i.p.). At 3 days after KA injection, we examined neuronal cell death in hippocampus using cresyl violet stain (A) and DNA fragmentation as a marker for apoptosis (B). The asterisks show the cell-loss regions compared to the vehicle (VHC) treated group. In the hippocampal neuron cell, we examined the effect of lovastatin after treatment of glutamate (GA: 200 µM) or KA (200 µM ) on the cell survival using MTT assay (C and D). The graphs indicate the S.E.M. (** P <0.01, *** P < 0.001 vs. the vehicle treated group; + P < 0.05, ++ P < 0.01 vs. the KA or GA treated group; n = 4 independent experiments).