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. Author manuscript; available in PMC: 2010 Jun 25.
Published in final edited form as: Neuron. 2009 Jun 25;62(6):788–801. doi: 10.1016/j.neuron.2009.05.012

Figure 7. Schematic of the principal pathways implicated by this study in conventional LTD (left) and in LTD facilitated by soluble Aβ oligomers (right).

Figure 7

Conventional LTD requires NMDAR-mediated influx of extracellular calcium and liberation of intracellular calcium stores. This ultimately activates PP2B, GSK-3β or p38 MAPK signaling pathways that induce LTD. Soluble Aβ oligomers lead to activation of more NMDAR, leading to extracellular calcium influx and activation of PP2B and GSK-3β pathways to facilitate LTD. Our data suggest that Aβ oligomers decrease glutamate uptake by neuronal transporters (red x's), resulting in the enhanced activation of NMDARs and thus facilitation of LTD-inducing pathways.