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. Author manuscript; available in PMC: 2010 Apr 18.
Published in final edited form as: Tetrahedron. 2009 Apr 18;65(16):3180–3188. doi: 10.1016/j.tet.2008.11.053

Scheme 1.

Scheme 1

Intramolecular Heck

(a) Amino ester, Et3N, DMAP, CH2Cl2; (b) Ethyl 4-bromocrotonate, K2CO3, CH3CN, 60 °C; (c) Amino ester, Et3N, DMAP, CH2Cl2; (d) 4-Buten-1-ol, DIAD, PPh3, CH2Cl2, RT; (e) Allyl bromide, K2CO3, CH3CN, RT; (f) Pd(OAc)2, PPh3, Et3N, CH3CN. (g) O3, CH2Cl2, −78 °C then Me2S.