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. Author manuscript; available in PMC: 2010 Apr 18.
Published in final edited form as: Tetrahedron. 2009 Apr 18;65(16):3180–3188. doi: 10.1016/j.tet.2008.11.053

Table 2.

Pd(0)-catalyzed C-arylation of substrates 12 and 14.a

graphic file with name nihms105787f8.jpg
entry SM product yieldb (%)
1 12a n = 0, R1 = Me, R2 = H 13a (83)
2 12b n = 0, R1 = Et, R2 = H 13b (77)
3 14a n = 1, R1 = Me, R2 = H 15a (85)
4 14b n = 1, R1 = Me, R2 = OMe 15b (56)
5 14c n = 1, R1 = Bn, R2 = H 15c (95)
a

Isolated yields

b

conditions: substrate (1.0 mmol), Pd(OAc)2 (0.1 mmol; 10.0 mol %), PPh3 (0.2 mmol), Cs2CO3 (2.0 mmol) in toluene (4.0 mL) at 110 °C in sealed tube for 12–24 h.