Figure 4.

Urinary bladder at the trigone area of female mice. (A) Wild-type mouse. (B) B6.129S6- Naglu^tm1Efn/J mutant mouse. 1, Mucosa; 2, lamina propria; 3, muscularis (detrusor muscle). Note the mononuclear infiltrate composed of single foamy granular cells (arrows), the loss of normal architecture of the bladder wall, submucosal edema, and denuded mucosa in (B) compared with the normal morphology of the urinary bladder of the wildtype mouse (A). Hematoxylin and eosin staining; scale bar, 100 μm.