Table 2.
Challenge dose (no. of CFU) | Clinical course | Time of euthanasia (no. of days postexposure) |
12 | No signs | NA |
16 | No signs | NA |
35 | Fever, followed by lethargy | 4 |
58 | No signs | NA |
122 | Fever, followed by lethargy and anorexia | 7 |
169 | Fever, followed by lethargy and anorexia | 5 |
174 | Fever followed by lethargy and anorexia | 5 |
198 | Fever followed by lethargy and anorexia | 7 |
208 | No signs | Died at 4 d postinoculation |
227 | No signs | NA |
262 | Fever followed by lethargy and anorexia | 7 |
264 | Fever followed by lethargy and anorexia | 7 |
295 | Fever followed by lethargy and anorexia | 5 |
353 | Fever followed by lethargy and anorexia | 4 |
374 | Fever followed by lethargy and anorexia | 7 |
479 | Fever followed by lethargy and anorexia | 3 |
759 | Fever followed by lethargy and anorexia | 4 |
3050 | No signs | Died at 5 d postinoculation |
4410 | Fever followed by lethargy and anorexia | 7 |
4850 | Fever followed by lethargy and anorexia | 4 |
12400 | Fever followed by lethargy and anorexia | Died at 5 d postinoculation |
42700 | Fever followed by lethargy and anorexia | Died at 5 d postinoculation |
NA, not applicable; these animals were euthanized at day 11 postexposure.
Each data point represents 1 animal.