Table 3.
Gross lesions induced after challenge with Y. pestis
| Dose of Y. pestis (CFU) | Gross necropsy findings |
| 12 | No significant gross lesions |
| 16 | No significant gross lesions |
| 35 | Moderate to marked bilateral fibrinous pneumonia |
| 58 | No significant gross lesions (myometrial congestion) |
| 122 | Moderate bilateral pneumonia; moderate hepatomegaly; moderate splenomegaly |
| 169 | Marked widespread bilateral fibrinous pneumonia; mild fibrinous pleural effusion; moderate splenomegaly |
| 174 | Moderate right unilateral pneumonia; marked splenomegaly |
| 198 | No significant gross lesions |
| 208 | Moderate bilateral pneumonia |
| 227 | No significant gross lesions |
| 262 | Moderate bilateral pneumonia |
| 264 | Moderate bilateral pneumonia; moderate splenomegaly |
| 295 | Marked bilateral pneumonia |
| 353 | Marked bilateral pneumonia |
| 374 | Marked bilateral pneumonia; moderate splenomegaly |
| 479 | Marked multifocal bilateral suppurative pneumonia; mild splenomegaly |
| 759 | Marked multifocal bilateral suppurative pneumonia; moderate TBLN lymphadenomegaly; mild spenomegaly |
| 3050 | Marked bilateral pneumonia; mild fibrinous pleural effusion; mild TBLN lymphadenomegaly; mild splenomegaly |
| 4410 | Marked left unilateral pneumonia with pleural/pericardial adhesions; moderate TBLN lymphadenomegaly; moderate splenomegaly |
| 4850 | Marked bilateral pneumonia; moderate TBLN lymphadenomegaly |
| 12400 | Mild bilateral epistaxis; marked bilateral pneumonia; marked, diffuse TBLN lymphadenopathy; moderate splenomegaly |
| 42700 | Marked bilateral pneumonia; marked TBLN lymphadenopathy; moderate splenomegaly |
TBLN, tracheobronchial lymph nodes.