Figure 2.

Pathology of RFHV infection of macaques. (A) Retroperitoneal fibromatosis (RF) occurs in macaques coinfected with SRV2 and RFHV. The lesion shares some similarities with human KS, and virus may be localized to the proliferating spindeloid cells, (B) which form short bundles and fascicles but lack the vascular channels observed in KS. The lesion often arises at the root of the mesentery but may eventually surround and encase the gastrointestinal tract into a single mass (insert). An antiHHV8 LANA rat monoclonal antibody demonstrates characteristic nuclear punctuate staining in (C) an RF lesion and (D) a lymph node with angiofollicular lymphocytic hyperplasia.