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. Author manuscript; available in PMC: 2009 Jun 29.
Published in final edited form as: Cell Host Microbe. 2008 Feb 14;3(2):67–76. doi: 10.1016/j.chom.2007.12.008

Figure 5. LTβ Expressed by B Cells Is Required for the Initial IFNαβ Response to MCMV.

Figure 5

B6, B-LTβ, and T-LTβ (mice lacking LTβ specifically in B and T cells, respectively) were infected with MCMV (2 × 105 PFU i.p.). Spleens were harvested 8 hr postinfection and the IFNβ, INFα, and ie1 mRNA levels were detected by qPCR and normalized to 18S rRNA. The ratio of IFNβ/ie1 mRNA (×100) is shown. Serum INFα levels were determined by ELISA. Statistical significance (*p < 0.05) was determined using the Student's t test, and fold differences are shown in parentheses. n = 4−6 mice per group; average of two independent experiments ± SEM.