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. Author manuscript; available in PMC: 2009 Jun 29.

Published in final edited form as: Horm Metab Res. 2009 Jan 20;41(4):261–270. doi: 10.1055/s-0028-1119377

Fig. 4 — System (entire circle) in negative energy balance. The contribution of the three components to the system has changed. The genome by assumption remains stable but physical activity and energy intake have increased and decreased, respectively. The effect of these changes is a decrease in internal energy via heat generation and the energy to restore the internal energy comes from energy intake and body stores. The model is based on the same assumptions stated in legend to Fig. 3. The size of the arrows of the wheels is proportional to the effect and the direction of the arrows indicates the movement of the energy fluxes. Wheels represent the regulatory interactions between the three components (genome, physical activity, energy intake) and the mechanisms controlling the internal energy.

Inline graphic — System (entire circle) in negative energy balance. The contribution of the three components to the system has changed. The genome by assumption remains stable but physical activity and energy intake have increased and decreased, respectively. The effect of these changes is a decrease in internal energy via heat generation and the energy to restore the internal energy comes from energy intake and body stores. The model is based on the same assumptions stated in legend to Fig. 3. The size of the arrows of the wheels is proportional to the effect and the direction of the arrows indicates the movement of the energy fluxes. Wheels represent the regulatory interactions between the three components (genome, physical activity, energy intake) and the mechanisms controlling the internal energy.