Table 1.

Results from redesigning 108 small proteins

Residue	Core residues (>20 Cβ atoms within 10 Å)					All residues
	No. correct	No. native	No. designed	No. correct/ No. native	No. correct/ No. designed	No. correct	No. native	No. designed	No. correct/ No. native	No. correct/ No. designed
Ala	78	114	137	0.68	0.56	226	645	779	0.35	0.29
Asp	0	9	2	0.00	0.00	84	465	538	0.18	0.16
Glu	0	11	1	0.00	0.00	121	607	902	0.20	0.13
Phe	43	76	103	0.57	0.42	103	286	361	0.36	0.29
Gly	35	48	39	0.73	0.90	389	555	560	0.70	0.69
His	0	11	5	0.00	0.00	3	174	34	0.02	0.10
Ile	63	112	128	0.56	0.49	135	482	360	0.28	0.37
Lys	3	20	9	0.15	0.33	109	642	788	0.17	0.14
Leu	92	131	174	0.70	0.53	263	675	667	0.39	0.39
Met	3	21	6	0.14	0.50	7	167	34	0.04	0.20
Asn	4	19	5	0.21	0.80	63	395	277	0.16	0.23
Pro	12	14	26	0.86	0.46	208	359	455	0.58	0.46
Gln	1	15	5	0.07	0.20	20	392	114	0.05	0.17
Arg	1	15	5	0.07	0.20	33	471	320	0.07	0.10
Ser	2	24	7	0.08	0.29	80	502	439	0.16	0.18
Thr	4	21	10	0.19	0.40	110	457	563	0.24	0.19
Val	83	139	153	0.60	0.55	187	568	466	0.33	0.40
Trp	8	19	16	0.42	0.50	26	94	114	0.28	0.23
Tyr	10	51	39	0.20	0.26	65	282	447	0.23	0.15
Total	444	870	870	0.51	0.51	2219	8218	8218	0.27	0.27

No. correct is the number of residue positions that have the same amino acid in the designed and native sequence. No. native and no. designed are the number of times an amino acid appears in the native and designed sequences, respectively. Cysteines were not varied in this study and were kept in their native conformation during design.