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. Author manuscript; available in PMC: 2009 Sep 26.
Published in final edited form as: Mol Cell. 2008 Sep 26;31(6):813–823. doi: 10.1016/j.molcel.2008.07.022

Figure 7. A Model for DGR Mutagenic Homing.

Figure 7

DGR homing occurs via a unique, “copy and replace” pathway that substitutes parental VR sequences with diversified cDNA copies of TR transcripts. cDNA integration at the 3′ end of VR is proposed to occur via a TPRT mechanism, while integration at the 5′ end of VR requires short stretches of TR/VR sequence homology and occurs through template-switching and/or strand displacement. Adenine mutagenesis most likely occurs during minus-strand cDNA synthesis by the DGR-encoded RT. The resulting mismatches in VR DNA strands could be resolved via DNA replication. Pink arrows and bars, cDNAs and cDNA-derived sequences. “N”, any of the four deoxyribonucleotides. Dashed lines, TR flanking sequences. See the text for details.