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H89 targets the CRE in BRCA1 promoter. A, The nucleic acid sequence of the BRCA1 proximal promoter; B, The activities of wildtype proximal BRCA1 promoter reporters (L6-Luc) is reduced by H89 treatment, and the mutant promter reporters without functional CRE (mCRE-Luc and USCAAT-Luc) abolish BRCA1 promoter activity.
