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. Author manuscript; available in PMC: 2010 Jul 1.
Published in final edited form as: Biochim Biophys Acta. 2009 May 3;1793(7):1199–1209. doi: 10.1016/j.bbamcr.2009.04.012

Figure 6.

Figure 6

Abnormal chemotactic movement of nlp/slp- cells. (A) DIC images of cells migrating toward a cAMP gradient at 0 or 10 min. Wild-type cells are usually well polarized, move quickly and linearly toward the cAMP source. nlp/slp- cells appear to have difficulties developing a psuedopod in the direction of the chemoattractant gradient. The expression of YFP-NLP alone mostly rescues motility defects. (B) The speed and chemotaxis index of nlp/slp- cells is significantly decreased compared to KAx3 cells, but recovered by the expression of NLP. Chemotaxis of at least 7 cells from two independent experiments was measured.