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. 2009 Mar 19;150(7):3401–3408. doi: 10.1210/en.2008-1800

Figure 3.

Figure 3

Ribbon diagram of homologous TSHR residues shown on the three-dimensional structure of FSH bound to the LRD of the FSHR. The FSHR structure is used because, although the TSHR LRD structure has been reported (16), the coordinates have not been entered into the NCBI Structure database but are only available in a patent application (40) that we are unable to use. The FSHR is shown in pink, and the FSH α and β-chains are blue and green, respectively. The data are from Fan and Hendrickson (15), NCBI, Molecular Modeling DataBase no. 31464, and Protein Data Base 1XWD. The structure is shown using Jmol (http://molvis.sdsc.edu/fgij/fg.htm?mol=http://opm.phar.umich.edu/pdb/1xwd.pdb). A, Lateral view looking into the LRD tube from its C-terminal side. B, Posterior view from the convex side of the slightly curved, tubular LRD, the ligand binding on the opposite convex surface. The SSD (or hinge region), whose structure and spatial relationship to the LRD is unknown, is depicted as a gray oval. TSHR amino acid residues 273 and 274 within the SSD comprise a discontinuous component to the CS-17 epitope.