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. 2009 Mar 12;150(7):3245–3251. doi: 10.1210/en.2009-0095

Figure 3.

Figure 3

Effect of icv PRL antagonist infusion on CS-induced PRL secretory rhythm. All animals were cervically stimulated at 1700 h of d 0 and 0900 h of d 1. OVX rats were infused with PRL antagonist (S179D, 0.1 ng/h) beginning around 1200 h of d 0. S179D infusion was maintained for 3 d (A) or 1 d (B). Blood samples were withdrawn during the next 2 d to observe the PRL diurnal and nocturnal surges (n = 5–11). Data are presented as mean ± sem. #, P < 0.05; ###, P < 0.001 vs. vehicle-injected group in the same time. *, P < 0.05; **, P < 0.01; ***, P < 0.001 vs. basal PRL on 2100 h of d 1 in the same experimental group.