Figure 6.

A model of the dynamics of coregulators, the histone modifications, and TR on the TRH gene in response to T₃. In the absence of T₃, TR, NCoR and phosphorylated Pol II are recruited to the TRH gene, H3K4 is methylated, and H3K9 and -K14 are acetylated. The addition of T₃ causes the recruitment of HDACs 2 and 3 to deacetylate H3K9 and -K14, and the amount of phosphorylated Pol II was decreased to suppress the gene. After the release of NCoR and HDACs, H3K9 and -K14 start to be reacetylated. Prolonged administration of T₃ causes demethylation of H3K4 and subsequently the release of TR from the gene to suppress the gene.