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. 2009 Mar 19;150(7):3145–3152. doi: 10.1210/en.2008-1740

Figure 2.

Figure 2

Effect of chronic GH treatment on plasma IGF-I, IGFBP-3, and ALS. WT and null ALS mice (null) were treated twice daily with GH (3 μg/g body weight per injection) or an equivalent volume of saline from 35 to 63 d of age. Blood was collected on d 63 of treatment. A, Plasma was analyzed for the concentration of IGF-I by RIA. B, Plasma was analyzed for the abundance of IGFBP-3 by ligand blotting and for the abundance of ALS by Western immunoblotting (top panel). Signals were quantified and shown in graphical forms (bottom panel). The significant effects of G (WT or null), H (saline or GH), and their interaction (G × H) are reported. Each bar represents the mean ± se of seven to nine female mice.