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. 2009 Apr 2;23(7):1022–1032. doi: 10.1210/me.2008-0477

Figure 2.

Figure 2

Schematic of putative DNA-regulatory elements in the rat PACAP gene promoter. Putative binding sites for cEts, GATA, nuclear factor of activated T cells (NFAT), AP-1, and the CRE were identified by sequence homology to reported mouse and rat consensus sequences using TESS web-based software. Each of these factors has been shown to mediate GnRH responsiveness in other genes (54). Promoter elements shown within this study to confer GnRH responsiveness to the PACAP promoter are boxed. The AP-1-like element at position −275 and the CRE-like element at position −205 in the rat PACAP gene will be characterized in detail.