Table 2.
Regional Rest-Specific Activity Over Time
| Coordinate | |||||||
|---|---|---|---|---|---|---|---|
| Region | Side | x | y | z | T-value | p value | Size (# voxels) |
| Stable Activity | |||||||
| Med Frontal Gyrus (10) | B | -2 | 58 | -4 | 9.20 | <0.001 | 6,507* |
| Ant Cingulate Gyrus (32) | B | 2 | 24 | -12 | 6.68 | <0.001 | 6,507* |
| Insula | R | 62 | -14 | 2 | 4.15 | <0.001 | 623 |
| Insula | L | -58 | -8 | 14 | 4.31 | <0.001 | 2,452+ |
| Temporal Pole (38) | R | 40 | 16 | -36 | 5.69 | <0.001 | 2,294 |
| Temporal Pole (38) | L | -40 | 14 | -30 | 3.45 | <0.001 | 2,452+ |
| Mid Temporal Gyrus (39) | R | 50 | -72 | 18 | 5.32 | <0.001 | 18,372¥ |
| Mid Temporal Gyrus (21) | R | 62 | -2 | -24 | 5.63 | <0.001 | 2,266 |
| Mid Temporal Gyrus (21) | L | -56 | -10 | -18 | 3.70 | <0.001 | 2,452 |
| Hippocampus | R | 24 | -6 | -20 | 3.23 | 0.001 | 1,084 |
| Hippocampus/Parahipp Gyrus (36) | L | -24 | -2 | -34 | 3.16 | 0.001 | 6,507* |
| Post Cingulate/Precuneus (31) | B | 0 | -66 | 20 | 11.34 | <0.001 | 18,372¥ |
| Mid Occipital Gyrus (19/37) | R | 52 | -74 | 4 | 3.87 | <0.001 | 18,372¥ |
| Mid Occipital Gyrus (19/37) | L | -42 | -74 | 4 | 3.44 | <0.001 | 18,372¥ |
| Decreased Activity | |||||||
| Sup Frontal Gyrus (10) | L | -14 | 50 | 8 | 4.81 | <0.001 | 153 |
| Insula | R | 42 | -16 | 0 | 3.80 | <0.001 | 875§ |
| Parahippocampal Gyrus (36)* | R | 28 | -26 | -18 | 4.41 | <0.001 | 875§ |
| Parahippocampal Gyrus (36) | L | -24 | -24 | -26 | 5.25 | <0.001 | 428 |
| Precuneus (7) | R | 8 | -36 | 50 | 5.09 | <0.001 | 463¢ |
| Precuneus (31) | L | -8 | -46 | 36 | 4.05 | <0.001 | 463¢ |
| Mid Occipital Gyrus (19) | R | 8 | -90 | 20 | 5.54 | <0.001 | 2,472 |
| Mid Occipital Gyrus (19/37) | L | -40 | -74 | 32 | 4.98 | <0.001 | 2,763 |
| Increased Activity | |||||||
| Mid Temporal Gyrus (21) | R | 54 | -14 | -10 | 3.90 | <0.001 | 192 |
| Mid Occipital Gyrus (19/37) | R | 50 | -68 | 0 | 4.32 | <0.001 | 1,195 |
*
Regions contained within the same cluster
+
Regions contained within the same cluster
¥
Regions contained within the same cluster
§
Regions contained within the same cluster
¢
Regions contained within the same cluster
Legend: Local maxima within default-mode regions exhibiting either stable or changing resting-specific activity from year 1 to year 9 as determined by the patterns of rCBF change in each area. Stereotaxic coordinates are listed; Brodmann areas are indicated in parentheses. *denotes change due to an increase in task-related rCBF as opposed to a decrease in resting rCBF.