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Cdk5 inhibitors dose-dependently inhibit peptide substrate phosphorylation in a SPA assay. A. Roscovitine dose-dependently inhibits substrate phosphorylation with IC50 280 nM. B. WL compound dose-dependently inhibits substrate phosphorylation with IC50 45 nM. C. AZ compound dose-dependently inhibits substrate phosphorylation with IC50 355 nM. Structures of these compounds are shown next to their respective inhibition curves.
