Fig. 2.

Modeling of tumor uptake of ⁶⁴Cu-labeled IT-101 using a 3-compartment model incorporating low molecular weight and nanoparticulate label. (A) Schematic diagram and governing equations describing the model. (B) Model fit for plasma and tumor concentrations including concentrations in the tumor interstitial space. (C) Apparent permeability for IT-101 (denoted ⁶⁴Cu NP) compared with dextran of varying molecular weight. Dextran was replotted based on data by Dreher et al. (11). See SI Appendix, Table S3 for definition of terms and values used in the simulations.