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. Author manuscript; available in PMC: 2010 Aug 1.

Published in final edited form as: J Mol Cell Cardiol. 2009 Apr 14;47(2):326–334. doi: 10.1016/j.yjmcc.2009.04.003

A. Bar graphs show mean I_TI density per cell in control conditions (open) and after exposure to 10 μM (left; n = 5), 50 μM (middle; n = 8) and 1000 μM (right; n = 4) ranolazine (closed). **: p<0.05, paired. B. Summary plot of the concentration-dependence ranolazine inhibition of I_Na peak (●), I_NaL (○) and I_TIs (). Smooth curves are best fits of concentration-response relationships to I_NaL, I_NaP and I_TI data (see Methods).

Inline graphic — A. Bar graphs show mean I_TI density per cell in control conditions (open) and after exposure to 10 μM (left; n = 5), 50 μM (middle; n = 8) and 1000 μM (right; n = 4) ranolazine (closed). **: p<0.05, paired. B. Summary plot of the concentration-dependence ranolazine inhibition of I_Na peak (●), I_NaL (○) and I_TIs (). Smooth curves are best fits of concentration-response relationships to I_NaL, I_NaP and I_TI data (see Methods).