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. Author manuscript; available in PMC: 2010 Aug 14.
Published in final edited form as: Brain Res Bull. 2009 May 3;79(6):345–350. doi: 10.1016/j.brainresbull.2009.04.012

Figure 1.

Figure 1

Membrane depolarization and action potentials (upper traces) in a current-clamped medium diameter rat DRG soma in response to a ramp of linearly increasing inward current (lower trace). The ramp’s slope was adjusted, to 0.5 nA/sec, so that the 1 sec long depolarization triggered 3 APs in control conditions (left side). When the same current ramp was applied to the same cell after 10min in 50nM ET-1, 6 APs were evoked (right side). S1 and S2 indicate the slow depolarizations during ramp stimulation leading to the first and second action potential.