Table 1.

Membrane parameters during ET-1 and in control conditions.

Parameter	Baseline	During ET-1	After ET-1	Ratio of during/before
RP [mV] (ET-1) (n=10)	-59.5 ± 3.4	-54.7 ± 3.31	-48.4 ± 6.9	0.92 ± 0.03
RP [mV] (C) (n=6)	-59.3 ± 4.3	-59.0 ± 4.4	-63.7 ± 5.8	0.99 ± 0.03
Rm [MΩ] (ET-1)	274 ± 46	282 ± 47	243 ± 50	1.03 ± 0.05
Rm [MΩ] (C)	240 ± 36	257 ± 55	272 ± 73	1.03 ± 0.10
#AP (ET-1)	3.0 ± 0.4*	5.9 ± 0.9*	5.0 ± 2.2	2.24 ± 0.41
#AP (C)	3.7 ± 0.4	4.0 ± 0.5	3.5 ± 1.1	1.13 ± 0.15
Vth AP1 [mV] (ET-1)	-30.5 ± 3.4	-31.2 ± 2.8	-24.6 ± 2.3	Δ = -1.3 ± 3.3 mV**
Vth AP1 [mV] (C)	-24.2 ± 6.1	-28.3 ± 3.7	-29.8 ± 5.4	Δ = -5.0 ± 8.4 mV
dV/dtrise [V/s] AP1 (ET-1)	54.8 ± 5.7	46.4 ± 5.00	35.4 ± 7.4	0.87 ± 0.08
dV/dtrise [V/s] AP1 (C)	47.2 ± 7.5	46.6 ±8.7	36.4 ± 5.1	1.01 ± 0.08
dV/dtfall [V/s] (ET-1)	-21.8 ± 4.1	-20.4 ± 3.7	-15.4 ± 1.4	0.95 ± 0.03
dV/dtfall [V/s] (C)	-22.4 ± 6.1	-21.2 ± 5.4	-20.3 ± 7.2	0.97 ± 0.03
dV/dtslow1 [V/s] (ET-1)	0.062 ± 0.019 *	0.084 ± 0.017 *	0.086±0.025	1.56 ± 0.24
dV/dtslow1 [V/s] (C)	0.058 ± 0.015	0.061 ± 0.023	0.057±0.020	1.06 ± 0.37
dV/dtslow2 [V/s] (ET-1)	0.100 ± 0.012 *	0.145 ± 0.012 *	0.148±0.015	1.52 ± 0.23
dV/dtslow2 [V/s] (C)	0.097 ± 0.016	0.088 ± 0.023	0.091±0.024	0.94 ± 0.19

^*Significant difference between parameter during baseline period and after 10 min in ET-1 (50nM). ANOVA.

^**Average of the difference between threshold voltage for the 1st AP before ET-1 and during ET-1 exposure.