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. 2008 Aug 21;68(8):1316–1321. doi: 10.1136/ard.2007.086728

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Serum macrophage migration inhibitory factor (MIF) levels before and 16 and 52 weeks after adalimumab therapy. The median values and ranges are shown for each time point. A large variability in MIF concentration was observed between patients. Some high pretreatment MIF concentrations may be due to the presence of MIF promoter polymorphisms in certain patients. The presence of such polymorphisms was not analysed in this study, the data, however, show that even high baseline MIF concentrations diminish significantly after anti-tumour necrosis factor alpha therapy.