Table 2. Changes in MIF levels and lipid profile over time.

	Week 0 (n  =  50)	Week 16 (n  =  50)	p Value	Week 52 (n  =  44)	p Value
MIF, pg/ml (IQR)	333 (90–1544)	171 (60–444)	0.020*	145 (60–335)	0.012*
Total cholesterol, mmol/l (SD)	4.86 (1.07)	5.06 (1.16)	0.053	4.98 (1.13)	0.301
HDL-cholesterol, mmol/l (SD)	1.52 (0.38)	1.66 (0.38)	<0.001*	1.62 (0.39)	0.061
LDL-cholesterol, mmol/l (SD)	2.88 (0.95)	2.96 (1.01)	0.392	2.93 (1.02)	0.577
Triglycerides, mmol/l (SD)	1.01 (0.51)	0.99 (0.54)	0.513	0.94 (0.43)	0.350
Apo A-I, mmol/l (SD)	1.46 (0.25)	1.56 (0.22)	<0.001*	1.56 (0.21)	0.005*
Apo B, mmol/l (SD)	0.99 (0.25)	1.00 (0.27)	0.465	0.99 (0.28)	0.816
Lp(a), mmol/l (IQR)	198 (65–356)	175 (65–377)	<0.001*	171 (47–375)	0.001*
Total cholesterol/HDL (SD)	3.33 (0.93)	3.15 (0.85)	0.034*	3.19 0.84)	0.272
Apo B/Apo A-I (SD)	0.70 (0.21)	0.65 (0.20)	0.014*	0.65 (0.20)	0.050
Glucose, mmol/l (SD)	5.13 (1.97)	4.95 (1.14)	0.847	5.04 (1.34)	0.930
CRP, mg/l (IQR)	8.8 (4.6–19.6)	3.8 (1.6–9.1)	<0.001*	2.7 (1.1–5.6)	<0.001*

Values are represented as mean (SD) or median and interquartile range (IQR).

*p Values <0.05 (two-sided) are significant.

Apo, apolipoprotein; CRP, C-reactive protein; HDL, high-density lipoprotein; LDL, low-density lipoprotein; Lp(a), lipoprotein (a); MIF, macrophage migration inhibitory factor.