Table 2.
Resuscitation Interventions Utilized in the Initial 6 h*
| Interventions | Before Group (n = 79) | After Group (n = 77) | p Value† |
|---|---|---|---|
| Endotracheal intubation | 7 (9) | 27 (35) | < 0.001 |
| Crystalloid volume, L | 2.54 ± 2.4 | 4.66 ± 1.8 | < 0.001 |
| Vasopressor administration | 27 (34) | 53 (69) | < 0.001 |
| Dobutamine administration | 1 (1) | 2 (3) | 0.61 |
| Packed RBC transfusion | 1 (1) | 4 (5) | 0.21 |
| Other | |||
| Time to initial antibiotics, min | 142 ± 117 | 99 ± 72 | 0.02 |
| Steroid administration‡ | 5 (6) | 31 (40) | < 0.001 |
| Activated protein C‡ | 3 (4) | 3 (4) | 0.99 |
*
Data are presented as No. (%) or mean ± SD.
†
Statistical analysis included t tests, Mann Whitney U, χ2, and Fisher exact tests as appropriate.
‡
Sepsis-specific variables that were followed but were not a part of the EGDT intervention protocol. Activated protein C was never administered in the ED or during the initial 6 h of therapy. Steroid administration was at the discretion of the attending physician in the ED or ICU but was not a part of the EGDT protocol.