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. Author manuscript; available in PMC: 2010 Apr 1.
Published in final edited form as: Addiction. 2009 Apr;104(4):518–532. doi: 10.1111/j.1360-0443.2009.02504.x

Table 1.

Linkage studies of cannabis use disorders

Author (Date) Phenotype Sample Highest LOD (chromosome, cM, LOD) Closest marker(s) Proposed gene(s)
Hopfer [20] DSM-IV cannabis dependence symptom count Adolescents from treatment centers and general population 3, 137 cM, 2.61
9, 156 cM, 2.57		 D3S1267
D9S1826		 Chr 3: MGL
Agrawal [21] DSM-IV cannabis dependence U.S. adults from dense multiplex alcoholic families 14, 95 cM, 1.90 rs759364-rs872945 Chr 14: GPR68, CKB, SERPINA1, SERPINA2
Agrawal [22] (i)DSM-IV cannabis dependence
(ii)Cannabis abuse/dependence factor score		 Australian adults from families ascertained for heavy cigarette smoking 1, 102 cM, 3.36
4, 38 cM, 2.22		 D1S2841
D4S419		 Chr 1: ELTD1
Chr 4: GABRA2
Agrawal [23] Lifetime frequency of cannabis use Australian adults from families from multiple sources 18, 96.8 cM, 2.10 GATA129F05_M Chr 18: Family of SERPINB genes, DOK6