Table 3.

Human association studies of the C385A (P129T, rs324420) promoter missense mutation in FAAH and substance-related phenotypes

Authors (Date)	Phenotype	Summary
Sipe [67]	Problem drug or alcohol use	A/A genotype associated with problem alcohol, drug and street drug use with odds-ratios ranging from 2.15 − 4.54
	Street drug use
	Street drug + problem drug/alcohol use
Morita [64]	Methamphetamine dependence	No association in this Japanese population
	Multi-substance abuse
Flanagan [66]	Drug addiction (alcohol or illicits)	A/A genotype associated with drug addiction in Caucasians (combined with Sipe et al gave odds-ratio of 3.2), in African Americans; underpowered in Asians;
*Tyndale [68]	In all and those who tried cannabis:	A/A genotype is associated with a 0.25 decrease in odds of cannabis dependence in those who try cannabis;
	Cannabis dependence	A/A genotype associated with increased odds of regular sedative use
	Regular alcohol, hallucinogen, nicotine, opiate, sedative, stimulant use
Iwasaki [65]	DSM-III-R alcohol dependence	No association in this Japanese population
*Haughey [45]	Marijuana Dependency Checklist	No association in 18−25 year old marijuana smokers for dependency, withdrawal, alcohol. C/C group have increased craving post-abstinence.
	Marijuana Withdrawal Checklist
	Profile of Mood States (POMS)
	Craving and Mood Questionnaire
	Alcohol consumption

^*Studied cannabis dependence specifically.