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. 2009 Jul 14;3(7):e475. doi: 10.1371/journal.pntd.0000475

Figure 1. Schematic diagram of the heme biosynthetic pathway.

Figure 1

The text in the boxes indicates the eukaryotic/prokaryotic/Wolbachia gene name. The asterisk indicates the gene missing in Wolbachia genome (PPO). ALAS, 5-aminolevulinate synthase (EC 2.3.1.37); ALAD, 5-aminolevulinate dehydratase (also known as PBGS, porphobilinogen synthase, EC 4.2.1.24); PBGD, porphobilinogen deaminase (EC 4.1.3.8); UROS, uroporphyrinogen-III synthase (EC 4.2.1.75); UROD, uroporphyrinogen-III decarboxylase (EC 4.1.1.37); CPO, coproporphyrinogen-IX oxidase (EC 1.11.1.10); PPO, protoporphyrinogen-IX oxidase (EC 1.3.3.4); FC, ferrochelatase (EC 4.99.1.1); SA, ALAD inhibitor Succinyl acetone; NMMP, FC inhibitor N-methyl mesoporphyrin.