Table 1. Reported schistosomicidal activity and inhibitory effect on heme crystallization by antimalarial compounds.

Drugs	Schistosomicidal activity	Inhibitors of heme crystallization*
Amodiaquine	−a	+b
Chloroquine	+a	+b
Mefloquine	+a	+b
Quinine	+a	+b
Halofantrine	+a	+b
Pyronaridine	−a	+b
Lumefantrine	+a	+c
Sulfadoxine	−a	−
Sulfamethoxypyrazine	−a	−
Atovaquone	−a	−
Pyrimethamine	−a	−

^aFrom Keiser et al [34].

^bFrom Ncokazi and Egan [53].

^cFrom Egan personal communication.

*: The reported inhibitory activity of antimalarial compounds on heme crystallization were obtained in synthetic reactions in vitro, and not in Schistosoma.