. 2009 Jul 14;3(7):e477. doi: 10.1371/journal.pntd.0000477

Table 5. Effect of daily doses (75 mg/kg/day, intraperitoneal route from 11^th to 17^th day post infection) of two quinoline methanols and an acridine on hemozoin content in S. mansoni, stratified by sex.

	No. mice	Mean hemozoin content in worms as nmols heme/mg protein (SEM)		Reduction in Hz content (%)
		Male	Female	Male	Female
Control	27	2.48 (0.35)	36.67 (3.97)	-	-
Quinine	27	1.95 (0.20)	21.90 (2.19)^a	21.37	40.28^c
Control	8	1.12 (0.19)	19.86 (1.52)	-	-
Quinidine	6	0.93 (0.30)	6.92 (0.91)^a	17.31	65.16^a
Quinacrine	6	0.84 (0.19)	18.46 (2.07)	25.54	7.05

Hemozoin content was obtained from S. mansoni worms recovered after mesenteric perfusion of control, quinine, quinidine, and quinacrine-treated mice 42 days after infection. Statistical analyses between groups were performed by using ANOVA and a posteriori Tukey's test.

p<0.001.

p<0.05 compared to control.

SEM, standard error from mean.

Table 5. Effect of daily doses (75 mg/kg/day, intraperitoneal route from 11th to 17th day post infection) of two quinoline methanols and an acridine on hemozoin content in S. mansoni, stratified by sex.

Table 5. Effect of daily doses (75 mg/kg/day, intraperitoneal route from 11^th to 17^th day post infection) of two quinoline methanols and an acridine on hemozoin content in S. mansoni, stratified by sex.