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. Author manuscript; available in PMC: 2010 May 1.
Published in final edited form as: J Comb Chem. 2009;11(3):370–374. doi: 10.1021/cc800181y

Scheme 3.

Scheme 3

Synthesis of 3,4-dihydropyrazino[1,2-b]indazolesa

aReagents and conditions: (i) CDI, substituted ethylenediamine, pyridine, DCM, 5 h; (ii) 2-nitrobenzenesulfonyl chloride, lutidine, DCM, overnight; (iii) bromoketone/bromoacetate, DIEA, DMF, overnight; (iv) DBU, DMF, 30 min; (v) methanesulfonyl chloride, TEA, DCM, overnight; (vi) 50% TFA in DCM, 1 h; (vii) AcOH, 2 h; (viii) TEA, MeOH, overnight