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. Author manuscript; available in PMC: 2009 Jun 30.
Published in final edited form as: Eur J Pharmacol. 2008 Apr 1;587(1-3):118–123. doi: 10.1016/j.ejphar.2008.03.033

Fig. 2.

Fig. 2

Inhibition of NOS enzymes has no effect on burn-induced secondary hyperalgesia. Agent was given through the intrathecal catheter as a pretreatment, 5 min prior to burning the paw (B, indicated by the arrow) and immediately after determination of withdrawal thresholds at time 0. All data is depicted as the mean ± S.E.M. Pretreatment with saline, the lower dose of L-NAME (33 μg) and thiocitrulline (Thio) resulted in indistinguishable magnitudes and time courses of the response indicating no anti-allodynic effects. While 100 μg of L-NAME totally prevented the development of the secondary hyperalgesia, this was paralleled by an equivalent result following administration of the same dose of the non-active agent D-NAME. * = P≤ 0.05 compared to the vehicle treated group at the specified timepoint.