Table 2.
Promoter hypermethylation of TRGs and MINT loci in melanoma cell lines
| Cell lines | WIF1 | TFPI2 | RASSF1A | RARβ2 | SOCS1 | GATA4 | MINT17 | MINT31 | Markers methylated |
|---|---|---|---|---|---|---|---|---|---|
| M1 | M | M | M | M | M | M | M | M | 8 |
| M2 | M | M | M | M | M | M | M | M | 8 |
| M3 | M | M | M | M | M | M | M | M | 8 |
| M4 | M | M | M | M | M | U | M | M | 7 |
| M5 | M | M | M | M | M | M | U | M | 7 |
| M6 | U | M | M | M | M | U | M | M | 6 |
| M7 | M | M | U | M | U | M | M | M | 6 |
| M8 | U | U | M | M | M | U | M | M | 5 |
| M9 | M | U | U | M | M | M | U | M | 5 |
| M10 | U | U | U | U | U | U | U | M | 1 |
| M11 | U | U | U | U | U | U | U | U | 0 |
| M12 | U | U | U | U | U | U | U | U | 0 |
| Melanocyte | U | U | U | U | U | U | U | U | 0 |
| Dermal fibroblast | U | U | U | U | U | U | U | U | 0 |
| Methylated lines (%) | 58.3 | 58.3 | 58.3 | 75 | 66.7 | 50 | 58.3 | 83.3 |
Abbreviations: M, methylated; U, unmethylated.