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. 2009 Jul 9;4(7):e6207. doi: 10.1371/journal.pone.0006207

Figure 4. IL-6KO mice have increased monocyte/macrophage infiltration into the heart at 7 days post infection.

Figure 4

Heart infiltrate was measured by flow cytometry analysis at 7 days post treatment with CB3/LPS. Cardiac infiltrate determined based on forward and side scatter as well as CD11b and CD11c immunostaining. IL-6KO mice had significantly increased monocyte/macrophage infiltration at 7 days post treatment compared to wt mice (C57BL/6 n = 9, IL-6KO n = 11) (black bars indicate wt mice, white bars indicate IL-6KO mice) (mean±SE, *p<0.05). This increased correlated with the elevated levels of the chemokine MCP-1 in IL-6KO mice and suggests a link between these two factors.