Table 3.
Eicosanoid synthesis and actions
| Eicosanoid | Cell/tissue origin | Target cell/tissue | Receptor | Action |
| PGE2 | Most cells | Many cells | EP1-EP4 | Fever, pain |
| PGI2 | Endothelium | Platelet VSMC | IP | Declumping, vasodilation |
| PGF2 | Uterus | Uterine SMC | FP | Contraction |
| PGD2 | Mast cells | Lung Th2 cells | DP1/DP2 | Asthma, chemotaxis |
| TXA2 | Platelets | Platelet VSMC | TPα/TPβ | Aggregation, vasoconstriction |
| LTB4 | Macrophage monocytes | Neutrophils | BLT1/BLT2 | Promotes chemotaxis |
| LTC4/LTD4/LTE4 | Macrophage monocytes | Lung SMC | BLT3/BLT4 | Bronchoconstriction |
| LXA4 | Leukocytes | Neutrophil | LXA4 R | Inhibits chemotaxis |
| LXB4 | Leukocytes | NK cells | ? | Inhibits cytotoxicity |