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. 2009 Apr 30;37(Web Server issue):W384–W389. doi: 10.1093/nar/gkp308

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© 2009 The Author(s)

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Surface conservation index of the split pocket in the human mitogen-activated protein kinase (PDB1ouk.A). (a) The split pocket (the 22th pocket) has the highest conservation index (0.703). Catalytic residues {K¹⁵², S¹⁵⁴, N¹⁵⁵} colored in cyan are located on the protein binding surface. (b) The spatial pattern of (a) consists of 26 residues with conservation weights for assessing the degree of evolutionary conservation.