Table 1.

HIF-1 target genes

Erythropoiesis/ Iron Metabolism	Cell Survival/ Proliferation	Angiogenesis	Vascular tone	Glucose Metabolism	Matrix Metabolism
EPO	IGF2	VEGF	NOS2	HK1,2	MMPs
Tf	TGF-α	Leptin	HO1	LDHA	PAR/PAI
Tfr	ADM	TGF-▯3	ET1	PKM	Coll PHD
Ceruloplasmin	BNip3	EG-VEGF	ADM	PFKL
	NIX		α1b	PGK1
	NDRG2			PFKFB3
				GAPDH
				GLUT1,3
				ENO1
				CA-9
				ALD-A,C
				AK-3

α1b, α1b-adrenergic receptor; ADM, adrenomedulin; AK, adenylate kinase; ALD, aldolase; BNip3, Bcl-2/adenovirus EIB 19kD-interacting protein 3; CA, carbonic anhydrase; Coll PHD, collagen prolylhydroxylases; EG-VEGF, endocrine gland-derived VEGF; ENO, enolase; EPO, erythropoietin; ET, endothelin; GAPDH, gylceraldehyde phosphate dehydrogenase; GLUT, glucose transporters; HK1,2, hexokinase 1,2; HO, heme oxygenase; IGF, insulin-like growth factor; LDH-A, lactate dehydrogenase-A; MMP, matrix metalloproteinases; NDRG, N-Myc downstream-regulated genes; NIX, Nip 3-like protein X; NOS, nitric oxide synthase; PAR/PAI, plasminogen activator receptors and inhibitors; PGK1, phosphoglycerate kinase 1; PFKL, phosphofructokinase L; PKM, pyruvate kinase M; TGF, transforming growth factor; TF, transferrin; Tfr, Tf receptor.